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Gerhardt, Mark A. MD PhD


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410 W 10th Ave
Columbus, OH 43210

Phone: (614) 293-8487

Email: gerhardt.15@osu.edu

 

Current OSU Appointments

Associate Professor, Anesthesiology

Associate Professor, Pharm CBO/Coll

 

Biographical

OTHER EXPERTISE

American Board of Anesthesiology certification, 1998



National Board of Echocardiography certification



Perioperative Transesophageal Echocardiography certification, 2000



Ohio Medical License, 35.074510, 1998

Academic Advising

Residents
1998 Eugene W. Moretti, MD (Duke University)
1998-2001 Terry Kim, MD (Chief Resident, 2000-2001)
1999-2002 Matthew L. Schlossberg, MD (Chief, 2001-02)
1999-2002 Joseph Zaki, MD (Chief Resident, 2001-2002)
2000-2003 John Haid, MD
2001-2004 Wenshi Gao, MD
2003-2005 Brad Michel, MD
2003-2006 John Swain, MD (Chief Resident, 2005-2006)
2004-2007 Thomas Smith, MD
2007-2010 Feyce Peralta, MD

Chapters in Books

Chapter 21: Endocrinology and Anesthetic Considerations

Anesthesia for foot and ankle surgery.

Chapter 3: Monitoring the Cardiac Surgical Patient

Chapter 9: Postoperative Care of the Cardiac Surgical Patient

Cardiothoracic Trauma

Chapter 2, Cardiovascular Pharmacology

Anesthesia for fetal surgery

 

Conferences

Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass - Impairment of the adenylyl cyclase moiety

beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i)

Neuroprotection is associated with beta-adrenergic receptor antagonists during cardiac surgery: Evidence from 2,575 patients

Progressive accumulation of myocardial desmin in an ovine model of chronic, ischemic heart failure

 

Honors

2010 Best (Abstract) of AHA Speciality Conferences at Scientific Sessions 2010. American Heart Association.
 

Journal Articles

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"Sex differences in severe pulmonary emphysema." American Journal of Respiratory and Critical Care Medicine. Vol. 176, no. 3. (January 2007.): -.

 

Reference Works

January 1987 Shams G, Romstedt KJ, Gerhardt MA, Harrold MW, Miller DD, Feller DR."Pharmacological studies of l-benzyl substituted trimetoquinol (TMQ) analogs as beta-adrenergic agonists and thromboxane A2 antagonists." . : 1145
January 1988 Gerhardt MA, Neubig RR."Epinephrine potentiates the ADP-induced calcium response in human platelets." . : A398
January 1989 Gerhardt MA, Wade SM, Neubig RR."[125I]-pIodoclonidine binding to platelet α2-adrenergic receptors." . : A900
January 1991 Dalman HM, Gerhardt MA, Neubig RR."Differential effects of α2A-adrenergic receptor peptides on G-proteins." . : A1594
January 1991 Gerhardt MA, Neubig RR."α2A-Adrenergic receptors (α2A-AR) efficiently inhibit adenylate cyclase in transfected CHO-K1 cells." . : A1594
January 1991 Shin Y, Romstedt KJ, Doyle K , Harrold MW, Gerhardt MA, Miller DD, Patil PN, Feller DR."Pharmacologic antagonism of thromboxane A2 (TXA2) receptors by trimetoquinol (TMQ) analogs in vitro and in vivo." . : A901
January 1992 Gerhardt MA, Neubig RR."Coupling of the α2A-adrenergic receptor to the G-proteins Gi2 and Gi3" . : A1552
January 1997 Atwell DM, Gerhardt MA, Newman MF, Mythen MG.."Use of an automated on-line tonometer (the Tonecap) as a monitor of gastric mucosal perfusion in cardiac surgery patients." . : SCA88
January 1997 Gerhardt MA, Chesnut LC, Funk BL, Landolfo KP, Schwinn DA.."Acute myocardial β-adrenergic receptor desensitization during cardiopulmonary bypass in patients with cardiac valve disease." . : A595
January 1998 Gerhardt MA, Barnett TN, Barry WT, Schwinn DA, Kwatra MM.."β2-adrenergic receptors in human atrial membranes activate both Gs and Gi." . : A206
January 1998 Gerhardt MA, Moretti EW, Chaudhry UA, Newman MF, Arrowsmith JE.."The safety of intraoperative high dose magnesium administration in cardiac surgical patients." . : A206
January 1998 Gerhardt MA, Chesnut LC, Funk BL, Landolfo KP, Kwatra MM, Schwinn DA.."Acute myocardial β-adrenergic receptor desensitization during cardiopulmonary bypass in patients with cardiac valve disease." . : 302
January 1999 Grigore AM, Amory DW, White WD, Gerhardt MA, Smith PK, Schwinn DA, Newman MF.."Beta-blockade and neurological outcome in cardiac surgery." . : SCA89
January 2000 Reilley TE, Chen E, Michelson C, Gerhardt MA.."Dose-finding study of intrathecal morphine in patients undergoing total hip arthroplasty." . : A865
January 2000 Abrishamchian AR, Gowdamarajan A, Gerhardt MA, Goldstein AH.."Creation of a large animal model of stable, ischemic, congestive heart failure." . : 156
January 2001 Gerhardt MA, Miller RJ."A dosing technique for labor epidurals that reduces the incidence of hypotension." . : A1138
January 2002 Goldstein AH, Monreal G, Kambara A, Spiwak AJ, Abrishamchian AR, Schlossberg ML, Gerhardt MA.."Partial unloading with a rotary ventricular assist device reduces myocardial oxygen consumption and stroke work in chronic heart failure." . : 163
January 2002 Monreal G, Gerhardt MA, Kambara A, Abrishamchian AR, Goldstein AH.."Ventricular remodeling of chronic, ischemic heart failure: progressive dilated cardiomyopathy despite stabilization of left ventricular ejection fraction." . : 163
January 2003 Gerhardt MA, Schlossberg ML, Reilley TE."Spinal anesthesia ± intrathecal morphine versus peripheral nerve block ± clonidine for pain control after total knee arthroplasty." . : A884
January 2003 Miller RJ, Gerhardt MA.."Intrathecal morphine dose-response following Cesarean section." . : A1060
January 2004 Monreal G, Goldstein AH, Kambara A, Schlossberg ML, Gerhardt MA."Partial support with a left ventricular assist device in chronic heart failure induces acute changes in myocardial electrolytes." . : A735
January 2004 Monreal G, Gerhardt MA."Increased Gαi-2 and decreased Gsαs levels in a microinfarction model of heart failure." . : SCA31
January 2005 Shao Y, Gravlee G, Gerhardt MA, Turner K, Awad H, Hachwa B, Howie MB."Right ventricular intramural hemotoma after aortic valve replacement - A case report." . : SCA1-116
January 2005 Monreal G, Goldstein AH, Gerhardt MA."Regional G protein alterations in an ovine model of chronic heart failure." . : S-340
January 2005 Gerhardt MA, Schanbacher BL, Monreal G, Goldstein AH, Bauer JA."Increased beta-adrenergic receptor density maintains left ventricular ejection fraction in an ovine model of chronic heart failure." . : S-336
January 2005 Monreal G, Goldstein AH, Gerhardt MA."Progressive accumulation of myocardial desmin in an ovine model of chronic, ischemic heart failure." . : S97
January 2006 Monreal G, Gerhardt MA."Increased PKA-mediated phosphorylation of myocardial beta-2 adrenergic receptors in a large animal model of chronic heart failure." . : S-40
January 2006 Xia Y, Gerhardt MA, McSweeney TD, Reilley TE.."Intrathecal neostigmine for knee surgery reduces total and first dose of postoperative analgesics." . : A332
January 2006 Monreal G, Bauer JA, Schanbacher BL, Gerhardt MA."Myocyte remodeling in an ovine model of chronic, ischemic heart failure." . : S-36
January 2007 Shao Y, Gravlee G, Gerhardt MA."Left atrial compression by collapsed left upper lobe lung causes acute pulmonary hypertension after cardiopulmonary bypass - a case report." . : SCA1-123
January 2007 Monreal G, Joshi MS, Bauer JA, Gerhardt MA."Alterations in the Acute Stress Protein αB-Crystallin in Chronic Heart Failure." .
January 2007 Gerhardt MA, Monreal G, Cook AC, Schanbacher BL, Han B, Huang H, Bauer JA."Intracellular remodeling: spatial mapping of desmin in chronic heart failure" .
January 2007 Monreal G, Gerhardt MA."Progressive accumulation of the acute stress protein αB-crystallin in an ovine model of chronic heart failure." . : S-39
January 2007 Phillips A, Monreal G, Galantowicz M, Gerhardt MA, Bauer JA."Cytoskeletal Remodeling in the Right Ventricle Caused by Pressure Restrictive Ventricular Septal Defect: A Potentially Important Clinical Marker." .
January 2007 Gerhardt MA, Monreal G, Schanbacher BL, Han B, Huang H, Phillips A, Bauer JA."Intracellular Remodeling: Spatial Mapping of Desmin in Chronic Heart Failure." .
January 2007 Phillips A, Monreal G, Cook AC, Bauer JA, Galantowicz M, Gerhardt MA."Desmin content in right and left ventricles in congenital heart disease: An indicator of heart failure." . : 1016-61
January 2007 Monreal G, Gerhardt MA."Myocardial Akt/GSK-3β phosphorylation is region-specific in an ovine model of microvascular heart failure." . : 2:039
January 2007 Phillips A, Monreal G, Galantowicz M, Gerhardt MA, Bauer JA."Desmin Content in Right and Left Ventricles in Congenital Heart Disease: An Indicator of Heart Failure." .
January 2007 Phillips A, Monreal G, Galantowicz M, Gerhardt MA, Bauer JA."Desmin Content in Right and Left Ventricles in Congenital Heart Disease: An Indicator of Heart Failure." .
January 2008 Monreal G, Phillips A, Wold LE, Bauer JA, Gerhardt MA."Alterations in β1-integrin and connexin-43 in restrictive ventricular septal defect." . : in press
January 2008 Monreal G, Han B, Joshi MS, Phillips A, Bauer JA, Gerhardt MA."Cytoskeletal remodeling of desmin is a more accurate measure of cardiac dysfunction than fibrosis and myocyte hypertrophy in ovine heart failure." . : S-17
January 2008 Phillips A, Monreal G, Galantowicz M, Bauer JA, Gerhardt MA."Right ventricular cytoskeletal remodeling in a porcine model of pressure restrictive ventricular septal defect." . : 1002-9
January 2008 Monreal G, Gerhardt MA."Spatial heterogeneity of the MAPK signaling cascades in an ovine model of heart failure." . : S-18
January 2008 Phillips A, Monreal G, Wold LE, Bauer JA, Gerhardt MA."Alterations in β1-integrin and connexin-43 in restrictive ventricular septal defect." .
January 2009 Monreal G, Nicholson LM, Phillips A, Bauer JA, Gerhardt MA."Endocardial desmin in heart failure" .
January 2010 Monreal G, Youtz DJ, Eyman ME, Phillips AB, Lucchesi PA, Wold LE, Gerhardt MA.."Subclinical Right Ventricular Remodeling in Restrictive Ventricular Septal Defect" .

Presentations

Epinephrine Potentiates the ADP-Induced Calcium Response in Human Platelets

Functional Expression of a2A-Adrenergic Receptor in CHO-K1 Cells

Acute ß-Adrenergic Receptor Desensitization During Cardiopulmonary Bypass

Safety of High Dose Magnesium Therapy in Cardiac Surgical Patients

ß-Adrenergic Receptor Coupling to Gi-Proteins

Thrombectomy through a Central Venous Catheter

Current Concepts in Cardiovascular Anesthesia, Part I and Current Concepts in Cardiovascular Anesthesia, Part II

Current Strategies for Managing Perioperative Ventricular Dysfunction

Thrombectomy through a Central Venous Catheter

Current Strategies for Managing Perioperative Ventricular Dysfunction

Continuous Infusion Epidural Anesthesia in Parturients with Cardiovascular Disease

Comparison of Two Labor Epidural Techniques on Hemodynamic Stability

Multiple Modalities of Airway Management in Trauma Patients

Current Strategies for Managing Perioperative Ventricular Dysfunction

Dose-Finding Study of Intrathecal Morphine in Patients Undergoing Total Hip Arthroplasty

Continuous Infusion Epidural Anesthesia in Parturients with Cardiovascular Disease

Milrinone in the Cardiac Surgical Patient

Milrinone in the Cardiac Surgical Patient

Modern Theories and Correction of Receptor Down Regulation in Congestive Heart Failure

Acute Partial Bypass with a Centrifugal Left Ventricular Assist Device Reduces Myocardial oxygen consumption in chronic, ischemic hearts

Ventricular Dysfunction and Dilatation Induced by Coronary Microembolization: A Twelve Month Documentation

Cardiac Anatomy and Imaging Workshop

Effects of Partial Unloading in the Chronic Ischemic Heart: An Ovine Model

Tension Pneumothorax During Lung Volume Reduction Surgery via Sternotomy

A Comparison of Spinal Anesthesia with and without Morphine versus Peripheral Nerve Block with and without Clonidine for the Control of Pain After Total Knee Replacement Surgery

Whole Animal Model of Ischemic Heart Failure, Ventricular Remodeling and Changes in Contractility Over Time

Inadvertent Placement of Epidural Catheter into Spinal Cord in an Intubated, ICU Trauma Patient

Non-Bolus Epidural Dosing Technique in a Parturient with TGA Following Atrial Switch (Mustard Procedure

Effects of Left Ventricular Partial Unloading on Chronic, Ischemic Heart Failure

Invasive Monitoring for Obstetric Patients

Anesthetic Considerations for the Pregnant Patient with Cardiac Disease

Improving Hemodynamic Stability and Peripartum Outcome in Parturients with Cardiac Disease

Intercostal and Paravertebral Nerve Blocks: The Epidural Alternative

Ventricular Dysfunction and Dilation Induced by Coronary Microembolization in Sheep

Partial Unloading with a Centrifugal Left Ventricular Assist Device Reduces Myocardial Oxygen Consumption in Chronic Heart Failure

The Use of TEE in Non-Cardiac Emergencies

Increased Gai-2 and Decreased Gsas Levels in a Microinfarction Model of Heart Failure

Case Report: Resection of a Left Ventricular Metastatic Malignant Melanoma

Increased ß1-Adrenergic Receptor Density Maintains Left Ventricular Ejection Fraction in an Ovine Model of Chronic Heart Failure

From Pathophysiology to Therapy: Development of a Sheep Model of Chronic Heart Failure

Regional G Protein Alterations in an Ovine Model of Chronic Heart Failure

Development of an Ovine Model of CHF with LVAD Implantation as Therapy

Blood Products in Cardiothoracic Surgery

Progressive Accumulation of Myocardial Desmin in an Ovine Model of Chronic, Ischemic Heart Failure

LVAD Therapy in Heart Failure: Is Less More?

Myocyte Remodeling in an Ovine Model of Chronic, Ischemic Heart Failure

LVAD Therapy in a Microembolization Model of Heart Failure

Cardioprotection during OPCAB

Increased PKA-mediated Phosphorylation of Myocardial Beta-2 Adrenergic Receptors in a Large Animal Model of Chronic Heart Failure

Progressive Accumulation of the Acute Stress Protein aB-Crystallin in an Ovine Model of Chronic Heart Failure

Cytoskeletal Remodeling in the Right Ventricle Caused by Pressure Restrictive Ventricular Septal Defect: A Potentially Important Clinical Marker

Desmin Content in Right and Left Ventricles in Congenital Heart Disease: An Indicator of Heart Failure

Desmin Content in Right and Left Ventricles in Congenital Heart Disease: An Indicator of Heart Failure

Intracellular Remodeling: Spatial Mapping of Desmin in Chronic Heart Failure

Alterations in the Acute Stress Protein aB-Crystallin in Chronic Heart Failure

Intracellular Remodeling: Spatial Mapping of Desmin in Chronic Heart Failure

Ventricular Remodeling in Heart Failure

Molecular Mechanisms in Heart Failure

Upregulation of the Intermediate Filament Desmin in Heart Failure

Rigth Ventricular Remodeling in Restrictive Ventricular Septal Defect

Rigth Ventricular Remodeling in Restrictive Ventricular Septal Defect

Desmin content in right and left ventricle in congenital heart disease, an indicator of heart failure

 

Professional Activities

2006 - present Associate Investigator, Heart & Lung Research Institute, The Ohio State University. Columbus, OH.
2010 - present Center for Clinical and Translational Science. Center for Clinical and Translational Science.
2001 - 2005 Society of Cardiovascular Anesthesiologists.
 

Technical Reports

Nationwide Children's Hospital. "Underlying Dysfunction of Seemingly Non-Critical Heart Condition Identified." ScienceDaily