Ohio State Navbar

Directory

Christofi, Fievos L. PhD


Staff photo

420 W 12th Ave
Columbus, OH 43210

Phone: (614) 688-3802

Email: christofi.1@osu.edu

 

Current OSU Appointments

Vice Chair, Anesthesiology

Professor, SBS-Physiology & Cell Biology

 

Chapters in Books

Christofi FL, Cook MA. "Purinergic Modulation of Gastrointestinal Function." In Purinergic Approaches in Experimental Therapeutics. Edited by Jacobson, K and Williams M. -. New York: Wiley Press, January 1997.

Harter R, Christofi FL. "Gastrointestinal Pharmacology." In Clinical Pharmacology for Anesthetists. Edited by Bovill and Howie. 309-320. Philadelphia: W.B. Saunders, January 1999.

Cooke HJ, Javed N, Christofi FL. "Enteric Neural Reflexes and Secretion. Autonomic Neuroimmunology." In Autonomic Nervous System. Vol. 16. Edited by Goetzl E, Lennerhassett M, Bienestock J. 35-59. Reading: Hardwood Academic Publishers, January 2003.

Cooke HJ, Christofi FL. "Enteric Regulation of Mucosal Secretion." In Physiology of the Gastrointestinal Tract. Fourth Edition ed. Edited by Johnson LR. 737-762. New York: Academic Press, January 2006.

 

Degrees

1988 Ph.D., University of Western Ontario

 

Honors

2003 - present Janssen Award in Gastroenterology. Janssen Pharmaceutica & EISAI.
 

Journal Articles

Christofi, FL; Cook, MA. "Antagonism by theophylline of the adenosine receptor agonist 5'-N-ethylcarboxamidoadenosine at the guinea pig ileum.." Canadian Journal of Physiology and Pharmacology. Vol. 63, no. 9. (September 1985.): 1195-1197.

Christofi, FL; Cook, MA. "Affinity of various purine nucleosides for adenosine receptors on purified myenteric varicosities compared to their efficacy as presynaptic inhibitors of acetylcholine release.." The Journal of Pharmacology and Experimental Therapeutics. Vol. 237, no. 1. (April 1986.): 305-311.

Christofi, FL; Cook, MA. "Possible heterogeneity of adenosine receptors present on myenteric nerve endings.." The Journal of Pharmacology and Experimental Therapeutics. Vol. 243, (January 1987.): 302-309.

McDonald, TJ; Christofi, FL; Brooks, BD; Barnett, W; Cook, MA. "Characterization of content and chromatographic forms of neuropeptides in purified nerve varicosities prepared from guinea pig myenteric plexus.." Regulatory Peptides. Vol. 21, no. 1-2. (May 1988.): 69-83.

Christofi, FL; McDonald, TJ; Cook, MA. "Adenosine receptors are coupled negatively to release of tachykinin(s) from enteric nerve endings.." The Journal of Pharmacology and Experimental Therapeutics. Vol. 253, no. 1. (April 1990.): 290-295.

Christofi, FL; McDonald, TJ; Cook, MA. "Neuropeptide release from isolated myenteric nerve endings derived from the guinea pig myenteric plexus.." Regulatory Peptides. Vol. 30, no. 2. (September 1990.): 165-177.

Christofi, FL; Palmer, JM; Wood, JD. "Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the guinea-pig small intestine.." European Journal of Pharmacology. Vol. 195, no. 3. (April 1991.): 333-339.

Christofi, FL; Tack, J; Wood, JD. "Suppression of nicotinic synaptic transmission by adenosine in myenteric ganglia of the guinea-pig gastric antrum.." European Journal of Pharmacology. Vol. 216, no. 1. (May 1992.): 17-22.

Christofi, FL; Hanani, M; Maudlej, N; Wood, JD. "Enteric glial cells are major contributors to formation of cyclic AMP in myenteric plexus cultures from adult guinea-pig small intestine.." Neuroscience Letters. Vol. 159, no. 1-2. (September 1993.): 107-110.

Christofi, FL; Wood, JD. "Effects of PACAP on morphologically identified myenteric neurons in guinea pig small bowel.." The American journal of physiology. Vol. 264, no. 3 Pt 1. (March 1993.): G414-G421.

Christofi, FL; Wood, JD. "Presynaptic inhibition by adenosine A1 receptors on guinea pig small intestinal myenteric neurons.." Gastroenterology. Vol. 104, no. 5. (May 1993.): 1420-1429.

Christofi Fl; Baidan LV; Fertel RL; Wood JD. "Adenosine A2 receptor - mediated excitation of a subset of AH / Type II neurons and elevation of cAMP levels in myenteric ganglia of guinea-pig small bowel." Neurogastroenterology and Motility. Vol. 6, (January 1994.): 67-78.

Christofi, FL; Wood, JD. "Electrophysiological subtypes of inhibitory P1 purinoceptors on myenteric neurones of guinea-pig small bowel.." British Journal of Pharmacology. Vol. 113, no. 3. (November 1994.): 703-710.

Christofi, FL; Guan, Z; Lucas, JH; Rosenberg-Schaffer, L; Stokes, BT. "Responsiveness to ATP with an increase in intracellular free Ca2+ is not a distinctive feature of calbindin-D28 immunoreactive neurons in myenteric ganglia.." Brain Research. Vol. 725, (January 1996.): 241-246.

Christofi, FL; Guan, Z; Wood, JD; Baidan, LV; Stokes, BT. "Purinergic Ca2+ signaling in myenteric neurons via P2 purinoceptors." The American Journal of Physiology (Gastrointest. Liver Physiol). Vol. 272, no. 3 Pt 1. (January 1997.): G463-G473.

Liu, CY; Zhang, H; Christofi, FL. "Adenylyl cyclase co-distribution with the CaBPs, calbindin-D28 and calretinin, varies with cell type: assessment with the fluorescent dye, BODIPY forskolin, in enteric ganglia.." Cell and Tissue Research. Vol. 293, no. 1. (January 1998.): 57-73.

Cooke, HJ; Wang, Y; Liu, CY; Zhang, H; Christofi, FL. "Activation of neuronal adenosine A1 receptors suppresses secretory reflexes in the guinea pig colon.." The American Journal of Physiology (GAstrointest. Liver Physiol). Vol. 276, (January 1999.): G451-G462.

Liu, CY; Jamaleddin, AJ; Zhang, H; Christofi, FL. "FlCRhR/cyclic AMP signaling in myenteric ganglia and calbindin-D28 intrinsic primary afferent neurons involves adenylyl cyclases I, III and IV.." Brain Research. Vol. 826, no. 2. (January 1999.): 253-269.

Zuo, L; Christofi, FL; Wright, VP; Liu, CY; Merola, AJ; Berliner, LJ; Clanton, TL. "Intra- and extracellular measurement of reactive oxygen species produced during heat stress in diaphragm muscle.." American Journal of Physiology. Cell Physiology. Vol. 279, no. 4. (January 2000.): C1058-C1066.

Barajas-Lopez, C; Espinosa-Luna, R; Christofi, FL. "Changes in intracellular Ca2+ by activation of P2 receptors in submucosal neurons in short-term cultures.." European Journal of Pharmacology. Vol. 409, no. 3. (January 2000.): 243-257.

Kim M, Xue J, Christofi F, Cooke HJ. "Mechanical stimulation activates Galphaq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells." Journal of Clinical Investigation. Vol. 108, no. 7. (January 2001.): 1051-1059.

Kim, Mm; Cooke, HJ' Javed, NH; Carey, HV; Christofi, F; Raybould HE. "D- glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells.." Gastroenterology. Vol. 121, (January 2001.): 1400-1406.

Christofi, FL; Zhang, H; Yu, JG; Guzman, J; Xue, J; Kim, M; Wang, YZ; Cooke, HJ. "Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system.." The Journal of Comparative Neurology. Vol. 439, (January 2001.): 46-64.

Christofi, F L. "Unlocking mysteries of gut sensory transmission: is adenosine the key?." News in Physiological Sciences (NIPS). Vol. 16, (January 2001.): 201-207.

Cooke, HJ; Wunderlich, J; Christofi, FL. ""The force be with you": ATP in gut mechanosensory transduction.." News in Physiological Sciences (NIPS). Vol. 18, (January 2003.): 43-49.

Cooke, HJ; Wang, Y-Z; Wray, D; O'Dorisio, MS; Woltering, EA; Coy, DH; Murphy, WA; Christofi, FL; Gosh, P; O'Dorisio, TM. "A multi-tyrosinated sst1/2 receptor preferring somatostatin agonist inhibits reflex and immune-mediated secretion in the guinea pig colon.." Regulatory peptides. Vol. 114, (January 2003.): 51-60.

Sundaram, U; Hassanain, HH; Suntres, Z; Yu, JG; Cooke, HJ; Guzman, J; Christofi, FL. "Rabbit chronic ileitis leads to up-regulation of adenosine A1/A3 gene products, oxidative stress, and immune modulation.." Biochemical Pharmacology. Vol. 65, no. 9. (January 2003.): 1529-1538.

Raybould, HE; Cooke, HJ; Christofi, FL. "Sensory mechanisms: transmitters, modulators and reflexes.." Neurogastroenterology and Motility. Vol. 16, no. Suppl 1. (January 2004.): 60-63.

Christofi, FL; Wunderlich, J; Yu, JG; Wang, Y-Z; Xue, J; Guzman, J; Javed, N; Cooke, HJ. "Mechanically evoked reflex electrogenic chloride secretion in rat distal colon is triggered by endogenous nucleotides acting at P2Y1, P2Y2, and P2Y4 receptors.." The Journal of Comparative Neurology. Vol. 469, no. 1. (January 2004.): 16-36.

Zuo, L; Christofi, FL; Wright, VP; Bao, S; Clanton, TL. "Lipoxygenase-dependent superoxide release in skeletal muscle.." Journal of Applied Physiology. Vol. 97, no. 2. (January 2004.): 661-668.

Cooke, HJ; Xue, J; Yu, JG; Wunderlich, J; Wang, Y-Z; Guzman, J; Javed, N; Christofi, FL. "Mechanical stimulation releases nucleotides that activate P2Y1 receptors to trigger neural reflex chloride secretion in guinea pig distal colon.." The Journal of Comparative Neurology. Vol. 469, no. 1. (January 2004.): 1-15.

Christofi, FL; Kim, M; Wunderlich, J, E; Xue, J; Suntres, Z; Cardounel, A; Javed, Najma, H; Yu, JG; Grants, I; Cooke, HJ. "Endogenous adenosine differentially modulates 5-hydroxytryptamine release from a human enterochromaffin cell model.." Gastroenterology. Vol. 127, no. 1. (January 2004.): 188-202.

Guzman, J; Yu, JG; Suntres, Z; Bozarov, A; Cooke, HJ; Javed, Najma; Auer, H; Palatini, J; Hassanain, HH; Cardounel, AJ; Javed, A; Grants, I; Wunderlich, JE; Christofi, FL. "ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis.." Inflammatory Bowel Diseases. Vol. 12, no. 8. (August 2006.): 766-789.

Chen, Z; Suntres, Z; Palmer, J; Guzman, J; Javed, A; Xue, J; Yu, JG; Cooke, HJ; Awad, H; Hassanain, HH; Cardounel, AJ; Christofi, FL. "Cyclic AMP signaling contributes to neural plasticity and hyperexcitability in AH sensory neurons following intestinal Trichinella spiralis-induced inflammation.." International Journal for Parasitology. Vol. 37, no. 7. (June 2007.): 743-761.

Kim, M; Christofi, FL; Xue, J; Robinson, JM; Cooke, H. "Mechanically evoked 5-hydroxytryptamine release is mediated by caveolin-associated cholesterol rich membrane domains.." Neurogastroenterology and Motility. Vol. 19, no. 4. (April 2007.): 309-317.

Emery, CF; Fondow, MD; Schneider, CM; Christofi, FL; Hunt, C; Busby, AK; Needleman, BJ; Melvin, WS; Elsayed-Awad, H. "Gastric bypass surgery is associated with reduced inflammation and less depression: a preliminary investigation.." Obesity Surgery. Vol. 17, no. 6. (June 2007.): 759-763.

Wunderlich, JE; Needleman, BJ; Chen, Z; Yu, JG; Wang, Y; Grants, I; Mikami, DJ; Melvin, WS; Cooke, HJ; Christofi, FL. "Dual purinergic synaptic transmission in the human enteric nervous system.." American Journal of Physiology. Gastrointestinal and Liver Physiology. Vol. 294, no. 2. (February 2008.): G554-G566.

Christofi FL. "Purinergic receptors and gastrointestinal secretomotor function.." Purinergic Signalling. Vol. 4, no. 3. (September 2008.): 213-236.

Awad H, Suntres Z, Heijmans J, Smeak D, Bergdall-Costell V, Christofi FL, Magro C, Oglesbee M. "Intracellular and extracellular expression of the major inducible 70kDa heat shock protein in experimental ischemia-reperfusion injury of the spinal cord.." Experimental Neurology. Vol. 212, no. 2. (August 2008.): 275-284.

Germano PM, Lieu SN, Xue J, Cooke HJ, Christofi FL, Lu Y, Pisegna JR. "PACAP induces signaling and stimulation of 5-hydroxytryptamine release and growth in neuroendocrine tumor cells." Journal of Molecular Neuroscience. Vol. 39, no. 3. (November 2009.): 391-401.

Bozarov A, Wang YZ, Yu JG, Wunderlich J, Hassanain HH, Alhaj M, Cooke HJ, Grants I, Ren T, Christofi FL. "Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine." American Journal of Physiology (Gastrointest Liver Physiol). Vol. 297, no. 6. (December 2009.): G1147-G1162.

Rybaczyk L, Rozmiarek A, Circle K, Grants I, Needleman B, Wunderlich JE, Huang K, Christofi FL.. "New bioinformatics approach to analyze gene expressions and signaling pathways reveals unique purine gene dysregulation profiles that distinguish between CD and UC.." Inflammatory Bowel Diseases. Vol. 15, no. 7. (July 2009.): 971-984.

Ren T; Grants I; Alhaj M; McKiernan M; Jacobson M; Hassanain HH; Frankel W; Wunderlich J; Christofi FL. "Impact of disrupting adenosine A(3) receptors (A(3) (-/-) AR) on colonic motility or progression of colitis in the mouse.." Inflammatory Bowel Diseases. Vol. 17, no. 8. (August 2011.): 1698-.

Ren T, Grants I, Alhaj M, McKiernan M, Jacobson M, Hassanain HH, Frankel W, Wunderlich J, Christofi FL.. "Disruption of adenosine A3 receptors (A3-/-AR) alters intestinal motility and protects mice from developing DSS- colitis." Inflammatory Bowel Disease. (January 2011.): -.

Schemann M, Bulmer D, Christofi FL. "Neurobiology of the Human Enteric Nervous System – Implications for Translational Neurogastroenterology." Neurogastroenterology and Motility. (January 2011.): -.

 

Reference Works

January 1985 Christofi FL, Cook MA."Comparison of the binding of PIA at isolated myenteric nerve varicosities with its biological activity" Southampton. : 165
January 1985 Christofi FL, Cook MA."Characterization of the adenosine receptor on myenteric nerve endings" . : 80
January 1985 Christofi FL, Cook MA."Identification and characterization of the adenosine receptor on myenteric nerve endings" . : 763
January 1986 Cook MA, Christofi FL."Release of neuropeptides from purified myenteric nerve endings obtained from the guinea-pig ileum" . : 119
January 1987 McDonald TJ, Christofi FL, Brooks BD, Cook MA."Neuropeptide content of guinea-pig myenteric nerve varicosities." . : 1525
January 1987 Christofi FL, McDonald TJ, Cook MA."The release of neuropeptide from the myenteric plexus of the guinea-pig ileum." . : A14
January 1987 Christofi FL, McDonald TJ, Cook MA."Regulation of substance P-mediated neurotransmission at the myenteric plexus by adenine nucleosides" . : 906
January 1988 Christofi FL, McDonald TJ, Cook MA."Tachykinin release from isolated myenteric varicosities prepared from guinea-pig ileum" . : 80
January 1989 Christofi FL, Palmer JM, Wood JD."Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the small intestine" . : A997
January 1989 Christofi FL, Palmer JM, Wood JD."Interactions between purinergic and cholinergic messages in the myenteric plexus of small intestine" . : A88

Professional Activities

2001 - 2004 Hamdy Hassanain - Young Faculty. The Ohio State University College of Medicine. Columbus, OH.
2001 - 2005 Mark Gerhardt - Young Faculty. The Ohio State University College of Medicine. Columbus, OH.
2001 - 2005 Hamdy Awad - Young Faculty. The Ohio State University College of Medicine. Columbus, OH.