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Research

Clinical Studies


The Department of Anesthesiology is involved in a number of industry-sponsored or Principal Investigator-initiated clinical studies to test new medications, intraoperative anesthesia monitoring equipment, and more. Some of these clinical studies include:
 

 Research Project Title

 Sponsor Name

 Prinicipal Investigator

A randomized, double-blind, double-arm trial comparing desflurane to sevoflurane for the effect on recovery time in patients undergoing urological cystoscope surgery under general anesthesia with a laryngeal mask airway (LMA) Baxter Healthcare Corp. Joseph G. Werner, MD
     
An extended pain relief trial utilizing the infiltration of a long acting multivesicular liposome formulation of bupivicaine, EXPAREL: a phase 3b health economic trial in adult patients undergoing laparoscopic colectomy Pacira Pharmaceuticals, Inc. Sergio D. Bergese, MD
     
An extended pain relief trial utilizing the infiltration of a long acting multivesicular liposome formulation of bupivicaine, EXPAREL: a phase 3b health economic trial in adult patients undergoing open colectomy Pacira Pharmaceuticals, Inc Sergio D. Bergese, MD
     
A multicenter, randomized, open-label, parallel-group trial to compare the efficacy and safety of the sufentanil Nanotab(R) PCA system/15 mcg to intravenous patient-controlled analgesia with morphine for the treatment of acute post-operative pain AcelRx Pharmaceuticals, Inc. Sergio D. Bergese, MD
     
Evaluating the correlation in blood glucose measurements between a continuous glucose monitoring (cgm) device and electroencephalogram (EEG) waves in intensive care unit patients N/A Thomas J. Papadimos, MD
     
Local anesthesia and sedation vs. general anesthesia for thoracoscopic procedures: is there a difference in patient outcome? A retrospective, case match controlled chart review analysis N/A Ryan E. Dalton, MD
     
A multi-center, open-label, surveillance trial to evaluate the safety and efficacy of a shortened infusion time of intravenous ibuprofen Cumberland Pharmaceuticals, Inc. Luis A. Lopez, MD
     
Respiratory function in hospital settings Covidien Sergio D. Bergese, MD
     
Epidural catheter migration: a cause and cure for labor epidural failure in the morbidly obese N/A Mara A. Grossman, MD
     
A randomized, double-blind, double-dummy, placebo-controlled, active-controlled, parallel-group, multicenter trial of oxycodone/naloxone controlled-release tablets (oxn) to assess the analgesic efficacy (compared to placebo) and the management of opioid-induced constipation (compared to oxycodone controlled-release tablets (oxy)) in opioid-experienced subjects with controlled moderate to severe chronic low back pain and a history of opioid-induced constipation who require around-the-clock opioid therapy Purdue Pharma L.P. Hans B. Miller, MD
     
A randomized, double-blind, placebo controlled safety, tolerability, and pharmacokinetic dose escalation study of DFA-02 in patients undergoing colorectal surgery Dr. Reddy's Laboratories, Inc. Sergio D. Bergese, MD
     
A phase 1, multicenter, open-label, single-dose study to assess the pharmacokinetics of ceftaroline fosamil/avibactam in adults with augmented renal clearance Cerexa, Inc. Sergio D. Bergese, MD
     
A multicenter, double-blind, randomized, phase 3 study to compare the efficacy and safety of intravenous cxa-201 with that of meropenem in complicated intraabdominal infections Cubist Pharmaceuticals, Inc. Stanislaw P. Stawicki, MD
     
A multicenter, double-blind, randomized, phase 3 study to compare the safety and efficacy of intravenous cxa-201 and intravenous levofloxacin in complicated urinary tract infection, including pyelonephritis Cubist Pharmaceuticals, Inc. Sergio D. Bergese, MD
     
A pilot study to determine the efficacy of intravenous ibuprofen for pain control following arthroscopic knee surgery Cumberland Pharmaceuticals, Inc. Fernando L. Arbona, MD
     
POISE-2: A large, international, placebo-controlled, factorial trial to assess the impact of clonidine and acetylsalicyclic acid (ASA) in patients undergoing non-cardiac surgery who are at risk of a perioperative cardiovascular event Public Health Research Institute Center (PHRI) Sergio D. Bergese, MD
     
Steroids in cardiac surgery Public Health Research Institute Center (PHRI) Michael S. Firstenberg, MD
     
Prospective, single center, randomized, double blind, placebo-controlled trial for the evaluation of the efficacy of 300mg or 600mg of pregabalin versus placebo in the reduction of pain and opioid consumption in patients with partial or full thickness burn injuries Pfizer Inc. Sidney F. Miller, MD
     
The evaluation of cleviprex in patients requiring ICP monitoring and IV antihypertensive therapy The Medicines Company Mario Ammirati, MD
     
Safety and efficacy of esmolol for the treatment of peri-operative tachycardia in patients at risk for post operative adverse ischemic outcomes Baxter Healthcare Corporation Demicha D. Rankin, MD
     

Randomized clinical trial of the safety and efficacy of brain tissue oxygen (Pbr02) monitoring in the management of severe traumatic brain injury
 
National Institutes of Health (NIH) John M. McGregor, MD
     
Neural bowel physiology and dysfunction in inflammatory bowel disease. National Institutes of Health Fedias L. Christofi, PhD
     
Studying the effectiveness of triple therapy with scopolamine, ondansetron and dexamethasone for prevention of post operative nausea and vomiting in high risk patients undergoing neurological surgery and general anesthesia. N/A Joseph G. Werner, MD
     
A prospective, randomized, double-blinded study assessing indices of SNAP II vs. Vista on surgical patients undergoing general anesthesia (Precision GA) Stryker Corporation Joseph G. Werner, MD
     
A retrospective review of the prevalence of methicillin resistant staphylococcus aureus (MRSA) in pre-operative cardiothoracic and neurosurgical patients. N/A Barbara M. Rogers, MD
     
A phase II, double-blind, placebo-controlled, dose finding study to evaluate the safety and efficacy of ipamorelin compared to placebo for the recovery of gastrointestinal function in patients following small or large bowel resection with primary anastomosis. Helsinn Therapeutics Sergio D. Bergese, MD
     
Aprepitant vs ondansetron in preoperative triple-therapy treatment of nausea and vomiting. N/A Sergio D. Bergese, MD

Updated July 23, 2012

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